Unimicellar hyperstars as multi-antigen cancer nanovaccines displaying clustered epitopes of immunostimulating peptides
Year: 2018
Type: article
Abstract: Unimicellar hyperstar macromolecular chimeras displaying multiple melanoma peptide antigens were prepared primarily via a combination of click chemistry and esterification reactions starting from a biodegradable hyperbranched polymer template. Solubilization of the hyperstars in aqueous solution afforded a multi-antigen unimicellar cancer nanovaccine of about 20 nm. The nanovaccine showed good biocompatibility and uptake by dendritic cells in vitro. An in vivo evaluation of the nanovaccine therapeutic efficacy against melanoma in mice implanted with B16OVA tumors revealed significantly greater T-cell recruitment and improved survival rates for mice treated with nanovaccine and adjuvant compared to non-treated mice.
Source: Biomaterials Science
DOI: 10.1039/c8bm00891d
Language: English
Subfield: Polymers and Plastics
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
Awards: Ultrasound imaging and enhanced therapeutic response, Optimized ultrasound-enhanced immunotherapy, Image-guided ultrasound therapy and drug delivery in pancreatic cancer, Large aperture and wideband modular ultrasound arrays for the diagnosis of liver cancer, Insonation of ultrasound microbubbles at low frequency to enhance image-guided therapy, Cancer Center Support Grant P30
OpenAlex ID: W2892240563