Work

Mechanisms of Regulated and Dysregulated CARD11 Signaling in Adaptive Immunity and Disease

Year: 2018

Type: article

Abstract: CARD11 functions as a key signaling scaffold that controls antigen-induced lymphocyte activation during the adaptive immune response. Somatic mutations in CARD11 are frequently found in Non-Hodgkin lymphoma, and at least three classes of germline CARD11 mutations have been described as the basis for primary immunodeficiency. In this review, we summarize our current understanding of how CARD11 signals, how its activity is regulated, and how mutations bypass normal regulation to cause disease.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2018.02105

Authors: Jacquelyn R. Bedsaul, Nicole M. Carter, Katelynn E. Deibel, Shelby M. Hutcherson, Tyler A. Jones, Zhaoquan Wang, Chao Yang, Yong-Kang Yang, Joel L. Pomerantz

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: NF-κB Signaling Pathways

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801

Funders: National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases

Awards: G171601887, G2205775429, Biochemistry, Cellular and Molecular Biology Program, Regulation of CARD11 signaling in normal and dysregulated lymphocyte development

OpenAlex ID: W2892332092

FWCI: 2.303

Cites: 100

Cited by: 82

Related to: 10