Chronic hepatitis B virus monoinfection at a university hospital in Zambia
Year: 2018
Type: article
Study design: Observational Study
Abstract: AIM: To characterize antiviral therapy eligibility among hepatitis B virus (HBV)-infected adults at a university hospital in Zambia. METHODS: clinical). Elevated ALT was > 19 in women and > 30 U/L in men. Among treatment-experienced individuals, we described medication side effects, adherence, and viral suppression. RESULTS: routine settings (adjusted odds ratio, 8.33; 95%CI: 2.26-29.41). Among 40 treatment-experienced HBV patients, virtually all took tenofovir, and a history of mild side effects was reported in 20%. Though reported adherence was good, 12 of 29 (41.4%) had HBV DNA > 20 IU/mL. CONCLUSION: Approximately one in ten HBV-monoinfected Zambians were eligible for antivirals. Many had indeterminate phenotype and needed clinical follow-up.
Source: World Journal of Hepatology
Institutions: University of Zambia, Tropical Gastroenterology & Nutrition group, Centre for Infectious Disease Research in Zambia, University of Bern, University Hospital of Bern, Ministry of Health, University of California, Los Angeles, University of Alabama at Birmingham, Queen Mary University of London, Blizard Institute, University of North Carolina at Chapel Hill
Language: English
Topic: Hepatitis B Virus Studies
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Awards: G4041153379, G596821015, G883697107
OpenAlex ID: W2892513636