Work

Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis

Year: 2018

Type: article

Abstract: Significance Retinoic acid (RA) is an important transcriptional regulator during both vertebrate and invertebrate body pattern formation. The Homeobox (Hox) gene family is activated by a gradient of RA formed along the length of the embryo at specific time points during fetal development. Generation of a genetically modified mouse harboring mutations in the SMRT repressor demonstrated that SMRT-dependent repression of retinoic acid receptor (RAR) is critical to establish and maintain the somitic Hox code and segmental identity during fetal development via epigenetic marking of target loci.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1809480115

Authors: Suk-Hyun Hong, Sungsoon Fang, Benson C. Lu, Russell Nofsinger, Yasuhiko Kawakami, Glenda L. Castro, Yunqiang Yin, Chengqi Lin, Ruth T. Yu, Michael Downes, Juan Carlos Izpisúa Belmonte, Ali Shilatifard, Ronald M. Evans

Institutions: Salk Institute for Biological Studies, Southeast University, Northwestern University, Howard Hughes Medical Institute

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: Howard Hughes Medical Institute, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: G303972377, Spatial Regulation of Developmental Gene Expression, Genetic regulation of progenitor cells in appendicular skeletal development, G9000105172, G9000125216

OpenAlex ID: W2892993745

FWCI: 0.707

Cites: 45

Cited by: 11

Related to: 10