Year: 2018
Type: editorial
Abstract: Viral infection of neurons is pathogenic, yet the factors that govern innate control of neurons remain incompletely understood. Using a Drosophila model we have defined the essential role that inflammatory-dependent Sting activation plays in inducing antiviral macroautophagy/autophagy to restrict Zika infection in the fly brain. Our discovery that Sting is an essential mediator of innate defenses in Drosophila provides further support for an ancient and conserved pathway that likely evolved to target intracellular pathogens for autophagic destruction.
Source: Autophagy
Authors: Yuan Liu, Sara Cherry
Institution: University of Pennsylvania
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
Awards: G9000105489, G9000352891
OpenAlex ID: W2893707798