Work

Recapitulation of molecular regulators of nuclear motion during cell migration

Year: 2018

Type: article

Abstract: Cell migration is a highly orchestrated cellular event that involves physical interactions of diverse subcellular components. The nucleus as the largest and stiffest organelle in the cell not only maintains genetic functionality, but also actively changes its morphology and translocates through dynamic formation of nucleus-bound contractile stress fibers. Nuclear motion is an active and essential process for successful cell migration and nucleus self-repairs in response to compression and extension forces in complex cell microenvironment. This review recapitulates molecular regulators that are crucial for nuclear motility during cell migration and highlights recent advances in nuclear deformation-mediated rupture and repair processes in a migrating cell.

Source: Cell Adhesion & Migration

DOI: 10.1080/19336918.2018.1506654

Authors: Alexandra Sneider, Jungwon Hah, Denis Wirtz, Dong-Hwee Kim

Institutions: Johns Hopkins University, Korea University

Language: English

Topic: Nuclear Structure and Function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,306