Work

Two Regulators, PA3898 and PA2100, Modulate the Pseudomonas aeruginosa Multidrug Resistance MexAB-OprM and EmrAB Efflux Pumps and Biofilm Formation

Year: 2018

Type: article

Abstract: It is generally believed that the Pseudomonas aeruginosa biofilm matrix itself acts as a molecular sieve or sink that contributes to significant levels of drug resistance, but it is becoming more apparent that multidrug efflux pumps induced during biofilm growth significantly enhance resistance levels. We present here a novel transcriptional regulator, PA3898, which controls biofilm formation and multidrug efflux pumps in P. aeruginosa .

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01459-18

Authors: Yun Heacock-Kang, Zhenxin Sun, Jan Zarzycki-Siek, Kanchana Poonsuk, Ian A. McMillan, Rungtip Chuanchuen, Tung T. Hoang

Institutions: University of Hawaiʻi at Mānoa, Chulalongkorn University

Language: English

Topic: Bacterial biofilms and quorum sensing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Department of Health and Human Services, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases

Awards: Functional Characterization of Essential Burkholderia pseudomallei Virulence Regulators, Functional Genomics of Single- and Mixed-Species Biofilms in Spatiotemporal Scale

OpenAlex ID: W2894802948

FWCI: 0.978

Cites: 65

Cited by: 32

Related to: 10