Work

Revisiting the role of metabolism during development

Year: 2018

Type: review

Abstract: An emerging view emphasizes that metabolism is highly regulated in both time and space. In addition, it is increasingly being recognized that metabolic pathways are tightly connected to specific biological processes such as cell signaling, proliferation and differentiation. As we obtain a better view of this spatiotemporal regulation of metabolism, and of the molecular mechanisms that connect metabolism and signaling, we can now move from largely correlative to more functional studies. It is, therefore, a particularly promising time to revisit how metabolism can affect multiple aspects of animal development. In this Review, we discuss how metabolism is mechanistically linked to cellular and developmental programs through both its bioenergetic and metabolic signaling functions. We highlight how metabolism is regulated across various spatial and temporal scales, and discuss how this regulation can influence cellular processes such as cell signaling, gene expression, and epigenetic and post-translational modifications during embryonic development.

Source: Development

DOI: 10.1242/dev.131110

Authors: Hidenobu Miyazawa, Alexander Aulehla

Institutions: European Molecular Biology Laboratory, European Molecular Biology Laboratory

Language: English

Topic: Metabolism, Diabetes, and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: Universität Heidelberg, Horizon 2020 Framework Programme, H2020 Marie Skłodowska-Curie Actions

Awards: EMBL Interdisciplinary, International and Intersectorial Postdocs, G968924281