Work

Bifidobacterial Dominance of the Gut in Early Life and Acquisition of Antimicrobial Resistance

Year: 2018

Type: article

Study design: Observational Study

Abstract: Infants are vulnerable to an array of infectious diseases, and as the gut microbiome may serve as a reservoir of AMR for pathogens, reducing the levels of AMR in infants is important to infant health. This study demonstrates that high levels of Bifidobacterium are associated with reduced levels of AMR in early life and suggests that probiotic interventions to increase infant Bifidobacterium levels have the potential to reduce AMR in infants. However, this effect is not sustained at year 2 of age in Bangladeshi infants, underscoring the need for more detailed studies of the biogeography and timing of infant AMR acquisition.

Source: mSphere

DOI: 10.1128/msphere.00441-18

Authors: Diana H. Taft, Jinxin Liu, Maria X. Maldonado-Gomez, Samir Akre, M. Nazmul Huda, S. M. Ahmad, Charles B. Stephensen, David A. Mills

Institutions: University of California, Davis, International Centre for Diarrhoeal Disease Research, Western Human Nutrition Research Center

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: gold

Estimated APC paid: $3,500

Funders: National Institutes of Health, University of California, Davis, National Center for Research Resources, National Center for Complementary and Integrative Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: Genome Sequencer FLX, Activation of probiotic bifidobacteria by milk glyans, Mechanism of Activation of Probiotic Bifidobacteria by Prebiotic Milk Glycans, Effects of Bifidobacterium Dominance on the Infant Microbiome, Illumina Sequencer to Facilitate Functional Genomics at Berkeley

OpenAlex ID: W2895270801

FWCI: 3.378

Cites: 68

Cited by: 107

Related to: 10