Work

Self-Assembling Protein Nanoparticles: Implications for HIV-1 Vaccine Development

Year: 2018

Type: article

Abstract: This technology could be adapted for HIV-1 vaccine development to present the V1V2 loop in a native-like conformation to induce high titers of binding, neutralizing and functional Abs, T-cell responses targeting multiple epitopes and subdominant epitopes, all of these will hopefully expand upon and improve the results of RV144."

Source: Nanomedicine

DOI: 10.2217/nnm-2018-0222

Authors: Christopher P Karch, Gary R Matyas, Peter Burkhard, Zoltan Beck

Institutions: Henry M. Jackson Foundation, Walter Reed Army Institute of Research

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: U.S. Department of Defense