Work

Defining an optimal time window to screen for hepatoblastoma in children with Beckwith‐Wiedemann syndrome

Year: 2018

Type: article

Abstract: Patients with Beckwith-Wiedemann spectrum (BWSp) undergo quarterly alpha-fetoprotein measurement for hepatoblastoma (HB) screening up to 4 years of age, paralleling the epidemiology of nonsyndromic HB. However, specific data on the timing of HB development in BWSp are lacking. Here we compare the timing of presentation of HBs in BWSp with a control cohort of consecutive HB cases, demonstrating that halving screening duration of screening procedures in BWSp likely will not impact its effectiveness.

Source: Pediatric Blood & Cancer

DOI: 10.1002/pbc.27492

Authors: Alessandro Mussa, Kelly A. Duffy, Diana Carli, Giovanni Battista Ferrero, Jennifer M. Kalish

Institutions: Azienda Ospedaliera Citta' della Salute e della Scienza di Torino, University of Turin, Children's Hospital of Philadelphia, University of Pennsylvania

Language: English

Topic: Genetic Syndromes and Imprinting

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute