Work

RAS variant signalling

Year: 2018

Type: review

Abstract: RAS proteins are small GTPases that regulate signalling networks that control cellular proliferation and survival. They are frequently mutated in cancer and a commonly occurring group of developmental disorders called RASopathies. We discuss recent findings describing how RAS isoforms and different activating mutations differentially contribute to normal and disease-associated biology and the mechanisms that have been proposed to underpin this.

Source: Biochemical Society Transactions

DOI: 10.1042/bst20180173

Authors: Stephanie P. Mo, Judy M. Coulson, Ian A. Prior

Institution: University of Liverpool

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,171