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Leisure‐time physical activity sustained since midlife and preservation of cognitive function: The Atherosclerosis Risk in Communities Study

Year: 2018
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: We tested the hypotheses that higher levels of and persistence of midlife leisure-time physical activity (LTPA) are associated long-term with lower cognitive decline and less incident dementia. METHODS: A total of 10,705 participants (mean age: 60 years) had LTPA (no, low, middle, or high) measured in 1987-1989 and 1993-1995. LTPA was assessed in relation to incident dementia and 14-year change in general cognitive performance. RESULTS: Over a median follow-up of 17.4 years, 1063 dementia cases were observed. Compared with no LTPA, high LTPA in midlife was associated with lower incidence of dementia (hazard ratio [95% confidence interval], 0.71 [0.61, 0.86]) and lower declines in general cognitive performance (-0.07 standard deviation difference [-0.12 to -0.04]). These associations were stronger when measured against persistence of midlife LTPA over 6 years. DISCUSSION: LTPA is a readily modifiable factor associated inversely with long-term dementia incidence and cognitive decline.
DOI: 10.1016/j.jalz.2018.08.008
Authors: Priya Palta, A. Richey Sharrett, Jennifer A. Deal, Kelly R. Evenson, Kelley Pettee Gabriel, Aaron R. Folsom, Alden L. Gross, B. Gwen Windham, David Knopman, Thomas H. Mosley, Gerardo Heiss
Institutions: University of North Carolina at Chapel Hill, Johns Hopkins University, The University of Texas at Austin, The University of Texas Health Science Center at Houston, University of Minnesota, University of Mississippi Medical Center, Mayo Clinic
Language: English
Field: Medicine
Open Access status: green
Awards: G1052397333, G1135917780, G1243299691, G1304838974, G1443812313, G1527150935, G1691174148, G173303992, G1941623656, G2195207551, G2818629771, G3114902838, Physical Activity and Preservation of Cognitive Function, G338088010, G3410686264, G3462919067, G4290615481, G457330776, G4577871212, ARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5, G4749522346, G5364873420, G567847597, G583528397, Intersection of Physiologic Frailty and Cognitive Performance in Older Adults: An Integrative Data Analysis, G6548750934, ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5, ARIC Neurocognitive Study (ARIC-NCS), G6978868085, G7804167723, Cardiovascular Epidemiology Training Grant
OpenAlex ID: W2895818198
FWCI: 3.286
Cites: 52
Cited by: 66
Related to: 10