Work

Impact of depth-dependent optical attenuation on wavelength selection for spectroscopic photoacoustic imaging

Year: 2018

Type: article

Abstract: An optical wavelength selection method based on the stability of the absorption cross-section matrix to improve spectroscopic photoacoustic (sPA) imaging was recently introduced. However, spatially-varying chromophore concentrations cause the wavelength- and depth-dependent variations of the optical fluence, which degrades the accuracy of quantitative sPA imaging. This study introduces a depth-optimized method that determines an optimal wavelength set minimizing an inverse of the multiplication of absorption cross-section matrix and fluence matrix to minimize the errors in concentration estimation. This method assumes that the optical fluence distribution is known or can be attained otherwise. We used a Monte Carlo simulation of light propagation in tissue with various depths and concentrations of deoxy-/oxy-hemoglobin. We quantitatively compared the developed and current approaches, indicating that the choice of wavelength is critical and our approach is effective especially when quantifying deeper imaging targets.

Source: Photoacoustics

DOI: 10.1016/j.pacs.2018.10.001

Authors: Heechul Yoon, Geoffrey P. Luke, Stanislav Y. Emelianov

Institutions: Georgia Institute of Technology, Dartmouth College, Emory University, The Wallace H. Coulter Department of Biomedical Engineering

Language: English

Topic: Photoacoustic and Ultrasonic Imaging

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,200

Funders: Breast Cancer Research Foundation, National Institutes of Health, National Cancer Institute