Work

Host-Pathogen Interactions: What the EHEC Are We Learning from Host Genome-Wide Screens?

Year: 2018

Type: article

Abstract: (EHEC). Their study revealed an unrecognized link between EHEC's two major virulence determinants (its T3SS and Shiga toxins). We discuss these findings in light of data from three other genome-wide screens. Each of these studies uncovered multiple host cell determinants, which curiously share little to no overlap but primarily are involved in mediating early interactions between T3SSs and host cells. We therefore consider how each screen was performed, the advantages and disadvantages of each, and how follow-up studies might be designed to address these issues.

Source: mBio

DOI: 10.1128/mbio.01837-18

Authors: Jason P. Lynch, Cammie F. Lesser

Institutions: Broad Institute, Harvard University, Massachusetts General Hospital

Language: English

Topic: Escherichia coli research studies

Subfield: Endocrinology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900