Work

The STAT3 and hypoxia pathways converge on Vasorin to promote stemness and glioblastoma tumorigenesis through Notch1 stabilization

Year: 2018

Type: article

Abstract: Gliomas are the most common primary intracranial neoplasms in adults and a leading cause of cancer-related morbidity and mortality in the United States (1). Grade I gliomas are considered the least malignant brain tumors, and grade IV or GBM the most aggressive and deadliest, which accounts for nearly 75% of all gliomas. Surgical resection of GBM remains the primary treatment modality with present adjuvant chemotherapy and radiation therapy only providing slight improvement in the disease course and outcome (2).

Source: Stem Cell Investigation

DOI: 10.21037/sci.2018.10.01

Authors: Meiyun Fan, Lawrence M. Pfeffer

Institution: University of Tennessee Health Science Center

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: U.S. Department of Defense, National Institutes of Health, National Cancer Institute