Work

The expanding world of biosynthetic pericyclases: cooperation of experiment and theory for discovery

Year: 2018

Type: article

Abstract: Covering: 2000 to 2018 Pericyclic reactions are a distinct class of reactions that have wide synthetic utility. Before the recent discoveries described in this review, enzyme-catalyzed pericyclic reactions were not widely known to be involved in biosynthesis. This situation is changing rapidly. We define the scope of pericyclic reactions, give a historical account of their discoveries as biosynthetic reactions, and provide evidence that there are many enzymes in nature that catalyze pericyclic reactions. These enzymes, the "pericyclases," are the subject of this review.

Source: Natural Product Reports

DOI: 10.1039/c8np00075a

Authors: Cooper S. Jamieson, Masao Ohashi, Fang Liu, Yi Tang, K. N. Houk

Institution: University of California, Los Angeles

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Science Foundation, National Institute of General Medical Sciences, Division of Chemistry

Awards: G2473705824, G4305609567, G8862415750