Work

Elevated Body Mass Index Is Associated with Secondary Hypogonadism Among Men Presenting to a Tertiary Academic Medical Center

Year: 2018

Type: article

Abstract: Purpose: To characterize the population of hypogonadal men who presented to a tertiary academic urology clinic and evaluate risk factors for primary vs. secondary hypogonadism.Materials and Methods: We evaluated all men with International Classification of Diseases-9 diagnosis codes R68.82 and 799.81 for low libido, 257.2 for testicular hypofunction, and E29.1 for other testicular hypofunction at a tertiary academic medical center from 2013 to 2017.We included men who had testosterone (T) and luteinizing hormone (LH) drawn on the same day.We classified men based on T and LH levels into eugonadal, primary, secondary, and compensated hypogonadism.Risk factors including age, body mass index (BMI) over 30 kg/m 2 , current smoking status, alcohol use greater than 5 days per week, and Charlson comorbidity index greater than or equal to 1 were investigated and measured in each group using the eugonadal group for reference.Results: Among the 231 men who had both T and LH levels, 7.4%, 42.4%, and 7.4% were classified as primary, secondary, and compensated hypogonadism, respectively.Only elevated BMI was associated with secondary hypogonadism compared to eugonadal men (median BMI, 30.93 kg/m 2 vs. 27.69kg/m 2 , p=0.003).BMI, age, comorbidities, smoking, or alcohol use did not appear to predict diagnosis of secondary hypogonadism.Conclusions: Secondary hypogonadism appears to be the most common cause of hypogonadism among men complaining of low T and decreased libido at a tertiary academic medical center.Secondary hypogonadism is associated with elevated BMI and therefore obesity should be used as a marker to evaluate men for both T and LH levels.

Source: The World Journal of Men s Health

DOI: 10.5534/wjmh.180047

Authors: John M. Masterson, Nachiketh Soodana-Prakash, Amir S. Patel, Atil Y. Kargi, Ranjith Ramasamy

Institution: University of Miami

Language: English

Topic: Hormonal and reproductive studies

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2896718879