Work

The effect of soft drink on proliferation, cell cycle analysis, and integrin expression of human foreskin fibroblast

Year: 2018

Type: article

Abstract: Cola is a globally distributed and consumed beverage.Soft drinks may contribute significantly to human health conditions and diseases associated with the Western Diet, consisting mainly of a high-volume intake of processed sugars, red meats and high fat foods.Ingredients comprising this beverage are undefined and may have an impact on the behavior of normal human cells, including the controlled cell proliferation, cell cycle and innate expression of ⍺5β1 integrin expression of human foreskin fibroblasts (HFF-1).The proliferation of HFF-1 was examined in the presence of an array of concentrations of Cola supplementation (0.5%, 1.0%, 1.5%, 2.0% 6.0%, 8.0%, and 10.0%) in conditions defined by the initial presence of 10μg/mL fibronectin.In the presence of increasing concentrations of Cola a decrease in the proliferation of HFF-1 cells is observed.Additionally, there are an increased proportion of HFF-1 cells in the G 1 phase in an environment consisting of increasing concentrations of Cola.There was no observed increase or decrease in the α5 or β1 integrin expression.With these findings, we suggest that more research should be conducting to better understand the effects resulting from Cola in larger concentrations.

Source: Journal of Applied Biotechnology & Bioengineering

DOI: 10.15406/jabb.2018.05.00140

Authors: Eckhart Kyle, Vaghasia Nikita, Kniseley Atherton, Bucci Brianna, Bill Tawil

Institutions: California State University System, University of California, Los Angeles

Language: English

Topic: Diet, Metabolism, and Disease

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: California State University Channel Islands