Trajectory of use over time of an oral tablet and a rectal gel for HIV prevention among transgender women and men who have sex with men
Year: 2018
Type: article
Abstract: We examined product adherence among 187 men who have sex with men and transgender women enrolled in a phase II, crossover trial comparing safety and acceptability of an oral tablet and a rectal gel used daily for HIV prevention. Participants reported adherence via daily text messages during 8-week periods. Trajectory analysis identified weekly patterns. Polytomous logistic regression identified characteristics associated with higher probability of trajectory group membership. We identified 3 groups per product: high-adherers (72% daily oral, 70% daily gel); decreasing-adherers (20% daily oral, 22% daily gel); and low-adherers (8% daily oral, 9% daily gel). Daily oral high-adherers (compared with low-adherers) were more likely to self-identify as male (OR = 4.76, 95% CI:1.35-16.67), to have more sexual partners (OR = 1.67, 95% CI:1.04-2.63), and to find the tablet easy to swallow (OR = 2.22, 95% CI:1.08-4.76). Daily gel high-adherers (compared with low-adherers) were more likely to be older (OR = 1.16, 95% CI:1.05-1.28), to find gel application easier at the last few applications (OR = 2.27, 95% CI:1.01-5.00), and to report a change in routine if gel was not used (OR = 5.26, 95% CI:1.23-100.00). Characteristics of participants likely to be high-adherers to product use vary according to product. Evaluation of acceptability prior to phase II/III trials could identify participants likely to maintain high adherence.
Source: AIDS Care
Institutions: New York State Psychiatric Institute, HIV Center for Clinical and Behavioral Studies, Columbia University, University of Pennsylvania, University of California, San Francisco, University of Washington, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Asociación Civil Impacta Salud y Educación, University of Pittsburgh
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1363540049, Microbicide Trials Network, Addressing disparities in chronic disease with a teen and young adult focus, Statistical and Data Management Center (SDMC): Microbicide Trials Network, Leadership and Operations Center (LOC): Microbicide Trials Network, The Next Frontier in Diabetes Communication: Promoting Health Literacy in the Era of Secure Messaging, Laboratory Center (LC): Microbicide Trials Network, Training in Biomedical Informatics at Columbia University, HIV Center for Clinical and Behavioral Studies
OpenAlex ID: W2896970558