Hog1 Regulates Stress Tolerance and Virulence in the Emerging Fungal Pathogen Candida auris
Year: 2018
Type: article
Abstract: The rapid global emergence and resistance of Candida auris to current antifungal drugs highlight the importance of understanding the virulence traits exploited by this human fungal pathogen to cause disease. Here, we characterize the stress resistance profile of C. auris and the role of the Hog1 stress-activated protein kinase (SAPK) in stress resistance and virulence. Our findings that C. auris is acutely sensitive to certain stresses may facilitate control measures to prevent persistent colonization in hospital settings. Furthermore, our observation that the Hog1 SAPK promotes C. auris virulence akin to that reported for many other pathogenic fungi indicates that antifungals targeting Hog1 signaling would be broad acting and effective, even on emerging drug-resistant pathogens.
Source: mSphere
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,919
Awards: Making and breaking the cell walls of fungal pathogens., G251240476, Wellcome Strategic Award for Medical Mycology and Fungal Immunology, Wellcome Strategic Award for Medical Mycology and Fungal Immunology, Making and breaking the cell walls of fungal pathogens., Mechanisms linking phosphate acquisition, stress resistance, and virulence in the fungal pathogen Candida albicans, Mechanisms directing stress-specific outputs from a regulatory hub - Hog1 in Candida albicans, G7269440194, G974971997
OpenAlex ID: W2896989720