Work

Multigenic Disease and Bilineal Inheritance in Dilated Cardiomyopathy Is Illustrated in Nonsegregating LMNA Pedigrees

Year: 2018

Type: article

Abstract: BACKGROUND: variant. We hypothesized that additional genetic cause may underlie DCM in these families. METHODS: variants. RESULTS: variant. CONCLUSIONS: Our data support DCM as a genetically heterogeneous disease with, at times, multigene causation. Although the frequency of DCM resulting from multigenic cause is uncertain, our data suggest it may be higher than previously anticipated.

Source: Circulation Genomic and Precision Medicine

DOI: 10.1161/circgen.117.002038

Authors: Jason R. Cowan, Daniel D. Kinnamon, Ana Morales, Lorien Salyer, Deborah A. Nickerson, Ray E. Hershberger

Institutions: University of Washington, The Ohio State University Wexner Medical Center, The Ohio State University

Language: English

Topic: Cardiomyopathy and Myosin Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green