Year: 2018
Type: review
Abstract: Cancer metastasis is a multistep process that requires cancer cells to leave the primary site, survive in the blood stream, and finally colonize at a distant organ. It is the major cause of cancer morbidity and mortality. The organ-specific colonization requires close interaction and communication between cancer cells and host organs. Noncoding RNAs represent the majority of the transcriptome, with long noncoding RNAs (lncRNAs) making up a significant proportion. It has been suggested that lncRNAs play a key role in all stages of tumorigenesis and metastasis. This review will provide an overview of how lncRNAs are involved in cancer cell colonization in specific organ sites and the underlying mechanisms as well as therapeutic strategies.
Source: Genes Chromosomes and Cancer
DOI: 10.1002/gcc.22691
Institution: The University of Texas MD Anderson Cancer Center
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
Awards: Investigating the regulation of miRNA and lncRNAs by p63 in mammary tumor progression and metastasis, G1758220818, Significance of Inhibiting Long Non-coding RNAs in Advanced Breast Cancer, Mechanistic Roles of Long mcRNA-regulated Gene Transcription in Prostate Cancer, G3394909115, Combinatorial Treatment Strategies to Counteract EGFR Resistance, PTEN Promotes Diabetic breast cancer metastasis, G4637640935, G5812937986, G698145331, Nuclear Architecture, NcRNAs and Epigenetics in Transcriptional Regulation by ER, G7607713948, G8619843213, Recruitment of First-Time, Tenure-Track Faculty Members
OpenAlex ID: W2897227202