Work

Pharmacokinetics of Sildenafil in Patients with a Left Ventricular Assist Device: A Word of Caution

Year: 2018

Type: article

Abstract: We compared maximal plasma concentrations (Cmax) of sildenafil and metabolite n-desmethyl sildenafil in 12 inpatients with left ventricular assist devices (LVADs) on sildenafil (60 mg/day) to the reference range. Sildenafil Cmax (156.8 ± 124.5 ng/ml) was elevated in 66% of patients, with a two to fivefold increase over the upper limit of the reference range in 25% of patients. Metabolite Cmax (133.3 ± 102.0 ng/ml) was elevated in 75% of patients, with a three to sevenfold increase over the upper limit of the reference range in 40% of patients. Patients with heart failure and LVADs are at increased risk of concentrated-related sildenafil adverse events.

Source: ASAIO Journal

DOI: 10.1097/mat.0000000000000886

Authors: Leah A. Sabato, Daniel C. Johnson, Nicholas Haglund, Mary Keebler, Zachary L. Cox

Institutions: Vanderbilt University Medical Center, University of Kansas Medical Center, Lipscomb University

Language: English

Topic: Mechanical Circulatory Support Devices

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Center for Advancing Translational Sciences