O3‐10‐02: a Preliminary Investigation on the Relationship Between Predicted Brain Age and Genetics in Alzheimer's
Year: 2018
Type: article
Study design: Observational Study
Abstract: In EOAD ε4+ and LOAD ε4group, correlation matrix of interregional 18 F-THK5351 retention revealed significant correlation in the more cortical regions (figure 2).Cognitive functions significantly correlated with cortical THK retention except for LOAD ε4-.Cerebrovascular disease markers, such as white matter hyperintensity volume, number of lacunes were greater in the LOAD ε4than LOAD ε4, whereas, those were not significantly different between EOAD ε4+ and EOAD ε-.Scatter plot indicating global 18 F-THK5351 retention in the x axis and global FMM retention in the y axis showed that those in the EOAD ε4+ and LOAD ε4+ were intermingled each other, whereas, EOAD ε4and LOAD ε4were quite different groups (figure 3).Conclusions: In EOAD ε4-, most of which were hippocampal sparing type of AD, tau and amyloid may develop more abruptly and independently.In LOAD ε4-, more complicated process including vascular or other degenerative pathologies or cognitive reservoir might be involved in the cognitive functions.While APOE4 carriers seemed to be typical AD clinically, the relationship between tau and amyloid may be different in EOAD and LOAD.
Source: Alzheimer s & Dementia
Authors: Brandalyn Riedel, Paul M. Thompson
Institution: University of Southern California
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2897462254