Work

Salvage regimens for pediatric patients with relapsed nasopharyngeal carcinoma

Year: 2018

Type: article

Abstract: There is no established salvage regimen for pediatric patients with relapsed nasopharyngeal carcinoma (NPC) and outcomes are dismal. We performed a multicenter retrospective review to determine outcomes after first salvage therapy for pediatric patients with relapsed NPC. Fourteen patients were treated with varied regimens. Two of the 14 patients received oxaliplatin-containing regimens and achieved a long-term complete response. Although definitive recommendations cannot be made based on outcomes for 14 patients who received varied regimens, we discuss justification for an oxaliplatin-containing regimen in combination with gemcitabine as a reasonable choice for first-line salvage therapy for pediatric patients with relapsed NPC.

Source: Pediatric Blood & Cancer

DOI: 10.1002/pbc.27469

Authors: Christopher DeRenzo, Catherine Lam, Carlos Rodriguez‐Galindo, Louis Rapkin, Stephen Gottschalk, Rajkumar Venkatramani

Institutions: Baylor College of Medicine, St. Jude Children's Research Hospital, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center

Language: English

Topic: Head and Neck Cancer Studies

Subfield: Otorhinolaryngology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute