PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies
Year: 2018
Type: article
Abstract: Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED) is the first prospective, observational cohort study of chronic pancreatitis (CP) in the United States. The primary goals of PROCEED are to define disease progression, test the predictive capability of candidate biomarkers, and develop a platform to conduct translational and mechanistic studies in CP. Using objective and consensus-driven criteria, PROCEED will enroll adults at different stages of CP-controls, suspected CP, and definite CP. In addition to collecting detailed information using structured case report forms and protocol-mandated evaluations at baseline and during follow-up, PROCEED will establish a linked biorepository of blood, urine, saliva, stool, pancreatic fluid, and pancreatic tissue. Enrollment for PROCEED began in June 2017. As of July 1, 2018, nine clinical centers of the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer are enrolling, and 350 subjects have completed baseline evaluation. In conclusion, PROCEED will provide the most accurate and reliable estimates to date on progression of CP. The established cohort and biorepository will facilitate numerous analyses, leading to new strategies for diagnosis, methods to monitor disease progression, and treatment of CP.
Source: Pancreas
Authors: Dhiraj Yadav, Walter G. Park, Evan L. Fogel, Liang Li, Suresh T. Chari, Ziding Feng, William E. Fisher, Christopher E. Forsmark, Christie Y. Jeon, Aida Habtezion, Phil A. Hart, Steven J. Hughes, Mohamed O. Othman, Jo Ann S. Rinaudo, Stephen J. Pandol, Temel Tirkes, Jose Serrano, Sudhir Srivastava, Stephen K. Van Den Eeden, David C. Whitcomb, Mark Topazian, Darwin L. Conwell
Institutions: University of Pittsburgh Medical Center, Stanford Medicine, Stanford University, Indiana University Hospital, Indiana University Indianapolis, Indiana University School of Medicine, The University of Texas MD Anderson Cancer Center, Mayo Clinic, Fred Hutch Cancer Center, Baylor College of Medicine, University of Florida Health, University of Florida, Cedars-Sinai Medical Center, The Ohio State University Wexner Medical Center, National Institutes of Health, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, Kaiser Permanente, Kaiser Permanente Northern California, University of Pittsburgh, UPMC Health System
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: The Ohio State University Chronic Pancreatitis Diabetes Pancreas Cancer (CPDPC) Clinical Center, DYSBIOTIC MICROBIOME IN PANCREATITIS, DIABETES, AND PANCREATIC CANCER, The Stanford Clinical Center for the Chronic Pancreatitis Research Consortium (CPCRC), UPMC Clinical Center for the Study of Chronic Pancreatitis and Diabetes, Indiana University (IU) Clinical Center for Chronic Pancreatitis Clinical Research Network, Cedars Sinai Center for the Chronic Pancreatitis Clinical Research Consortium, Chronic Pancreatitis Clinical Research Consortium (CPCRC) Data Coordinating Center (CPCRC-DCC), The Exocrine and Endocrine Pancreas in Type 2 Diabetes, Pancreatitis and Cancer
OpenAlex ID: W2897549962