Work

Depletion of tumor associated macrophages by anti-BAG3 treatment complements PD-1 blockade in pancreatic cancer

Year: 2018

Type: article

Abstract: New literature published in Gut has shown that combined treatment of anti-BAG3 mAb and anti-PD-1 mAb in pancreatic cancer can eliminate tumor-associated macrophages (TAMs), increase tumor infiltrating CD8+ T cells and result in tumor growth suppression (1). These findings highlight the potential of BAG3 (Bcl-2-associated athanogene 3) as a therapeutic target in conjunction with immune checkpoint blockade in the treatment of pancreatic cancer.

Source: Annals of Pancreatic Cancer

DOI: 10.21037/apc.2018.10.01

Authors: Yi Sun, Robert J. Torphy, Yuwen Zhu

Institutions: Peking University Cancer Hospital, University of Colorado Anschutz

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Centers for Disease Control and Prevention