Year: 2018
Type: article
Abstract: with ISM (median 47 years).The particular observation underscores the need to account for age when comparing survival between these WHO morphologic categories.The current study also suggests clustering of adverse disease features with SSM, when compared to ISM.Consistent with these differences in phenotype, univariate analysis favored ISM over SSM, in terms of survival.However, the difference in survival was not sustained during age-adjusted multivariable analysis that also included other previously established risk factors.By contrast, a similar analysis confirmed the independent survival effect of ASM, when compared to ISM.These observations suggest that functional consequences rather than mast cell burden dictate prognosis in SM.From a practical standpoint, when confronted with the diagnostic dilemma of distinguishing ISM from SSM, survival prediction appears to depend more on age and the presence or absence of risk factors, rather than the specific morphologic distinction.Finally, we emphasize the need for additional studies with larger number of informative cases, before endorsing the findings in the current study, considering the relatively small sample size.
Source: American Journal of Hematology
DOI: 10.1002/ajh.25310
Authors: Neeraj Y. Saini, Romil Patel, Ankur Varma, Qaiser Bashir, Ruby Delgado, Gabriela Rondon, Uday R. Popat, Chitra M. Hosing, Yago Nieto, Partow Kebriaei, Amin M. Alousi, Sairah Ahmed, Donna M. Weber, Sheeba K. Thomas, Hans C. Lee, Elisabet E. Manasanch, Krina K. Patel, Robert Z. Orlowski, Richard E. Champlin, Muzaffar H. Qazilbash
Institution: The University of Texas MD Anderson Cancer Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2897734208