Work

ESR1 fusions drive endocrine therapy resistance and metastasis in breast cancer

Year: 2018

Type: article

Abstract: Estrogen receptor alpha gene (ESR1) fusion transcripts have been identified in breast cancer but their role in breast cancer is not completely understood. Here, we report a causal role for ESR1 fusions in driving both endocrine therapy resistance and metastasis, and describe a therapeutic strategy to target ESR1 fusion-induced growth.

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2018.1526005

Authors: Jonathan T. Lei, Xuxu Gou, Matthew J. Ellis

Institution: Baylor College of Medicine

Language: English

Topic: Estrogen and related hormone effects

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,590