Work

H 2 S, a Bacterial Defense Mechanism against the Host Immune Response

Year: 2018

Type: article

Abstract: The biological mediator hydrogen sulfide (H 2 S) is produced by bacteria and has been shown to be cytoprotective against oxidative stress and to increase the sensitivity of various bacteria to a range of antibiotic drugs. Here we evaluated whether bacterial H 2 S provides resistance against the immune response, using two bacterial species that are common sources of nosocomial infections, Escherichia coli and Staphylococcus aureus .

Source: Infection and Immunity

DOI: 10.1128/iai.00272-18

Authors: Tracy Toliver-Kinsky, Weihua Cui, Gabor Törö, Seung-Jin Lee, Konstantin Shatalin, Evgeny Nudler, Csaba Szabo

Institutions: Shriners Hospitals for Children - Galveston, The University of Texas Medical Branch at Galveston, Howard Hughes Medical Institute, New York University, University of Fribourg

Language: English

Topic: Sulfur Compounds in Biology

Subfield: Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Defense, Howard Hughes Medical Institute, Blavatnik Family Foundation, Shriners Hospitals for Children, National Institutes of Health, National Institute of Allergy and Infectious Diseases

Awards: G3622891575, Inhibition of Bacterial and Host-Derived H2S Production for the Therapeutic Enhancement of Anti-Bacterial Host Defense, DEVELOPMENT OF INNOVATIVE COMBINATION THERAPY AGAINST MULTIDRUG-RESISTANT BACTERIA, G7765683143

OpenAlex ID: W2897801949

FWCI: 3.454

Cites: 27

Cited by: 93

Related to: 10