Year: 2018
Type: review
Abstract: Nutrient handling by higher organisms is a complex process that is regulated at the transcriptional level. Studies over the past 15 years have highlighted the critical importance of a family of transcriptional regulators termed the Krüppel-like factors (KLFs) in metabolism. Within an organ, distinct KLFs direct networks of metabolic gene targets to achieve specialized functions. This regulation is often orchestrated in concert with recruitment of tissue-specific transcriptional regulators, particularly members of the nuclear receptor family. Upon nutrient entry into the intestine, gut, and liver, KLFs control a range of functions from bile synthesis to intestinal stem cell maintenance to effect nutrient acquisition. Subsequently, coordinated KLF activity across multiple organs distributes nutrients to sites of storage or liberates them for use in response to changes in nutrient status. Finally, in energy-consuming organs like cardiac and skeletal muscle, KLFs tune local metabolic programs to precisely match substrate uptake, flux, and use, particularly via mitochondrial function, with energetic demand; this is achieved in part via circulating mediators, including glucocorticoids and insulin. Here, we summarize current understanding of KLFs in regulation of nutrient absorption, interorgan circulation, and tissue-specific use.
Source: Endocrine Reviews
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Awards: NRSA Training Core, Medical Scientist Training Program, Myeloid KLF2 mediates S-nitrosylation-driven vascular response to ischemic injury, KLF15 in skeletal muscle lipid metabolism, KLF control of aging and age-associated cardiovascular disease, Conserved transcriptional regulation of autophagy and lifespan by the Kruppel-like Factors, KLF2, monocyte activation and vascular inflammation, G6005064025, CWRU- Cardiovascular Research Training Program
OpenAlex ID: W2897859321