Work

ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases

Year: 2018

Type: article

Abstract: The activity of the siderophore cephalosporin cefiderocol is targeted against carbapenem-resistant Gram-negative bacteria. In this study, the activity of cefiderocol against characterized carbapenem-resistant Acinetobacter baumannii complex, Stenotrophomonas maltophilia , Pseudomonas aeruginosa , and Enterobacteriaceae strains was determined by microdilution in iron-depleted Mueller-Hinton broth.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01801-18

Authors: Michael R. Jacobs, Ayman M. Abdelhamed, Caryn E. Good, Daniel D. Rhoads, Kristine M. Hujer, Andrea M. Hujer, T. Nicholas Domitrovic, Susan D. Rudin, Sandra S. Richter, David van Duin, Barry N. Kreiswirth, Chris Greco, Derrick E. Fouts, Robert A. Bonomo

Institutions: University Hospitals Cleveland Medical Center, Case Western Reserve University, Louis Stokes Cleveland VA Medical Center, Cleveland Clinic, University of North Carolina at Chapel Hill, Rutgers New Jersey Medical School, J. Craig Venter Institute

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Department of Veterans Affairs, National Institutes of Health, National Institute of Allergy and Infectious Diseases

Awards: G1003374595, G1143233013, G1801780589, G3004358298, The J. Craig Venter Institute Genome Center for Infectious Diseases, G4070144744, G5879789260, G636376783, Understanding B-Lactam Resistance in Acinetobacter baumannii

OpenAlex ID: W2897987794

FWCI: 4.176

Cites: 28

Cited by: 108

Related to: 10