Work

The emergence of dihydroorotate dehydrogenase (DHODH) as a therapeutic target in acute myeloid leukemia

Year: 2018

Type: editorial

Abstract: The enzyme dihydroorotate dehydrogenase (DHODH) is essential for the de novo production of pyrimidines starting with the generation of uridine monophosphate (UMP), and small molecule inhibitors of ...

Source: Expert Opinion on Therapeutic Targets

DOI: 10.1080/14728222.2018.1536748

Author: David B. Sykes

Institutions: Harvard University, Massachusetts General Hospital, Harvard Stem Cell Institute

Language: English

Topic: Biochemical and Molecular Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: European Hematology Association, National Cancer Institute

Awards: G1660613235, Developing differentiation therapy for the treatment of patients with acute myeloid leukemia

OpenAlex ID: W2898021425

Cites: 19

Cited by: 111

Related to: 10