Get started
Work

Diet-quality scores and the risk of symptomatic gallstone disease: a prospective cohort study of male US health professionals

Year: 2018
Type: article
Study design: Observational Study
Abstract: Objective: To investigate the association between three diet-quality scores corresponding to adherence to healthy dietary patterns [alternate Mediterranean (aMed), Alternate Healthy Eating Index (AHEI-2010), Dietary Approaches to Stop Hypertension (DASH)] and the risk of symptomatic gallstone disease. Methods: The study comprised 43 635 men of the Health Professionals Follow-up Study-an ongoing prospective cohort study of US health professionals. Participants were free of symptomatic gallstone disease and diabetes and provided dietary information every 4 years from 1986 (baseline) until 2012. The aMed, AHEI-2010 and DASH scores were generated and associated with the risk of symptomatic gallstone disease using Cox proportional hazards regression. Results: During 716 904 person-years of follow-up, 2382 incident cases of symptomatic gallstone disease were identified. All three scores were inversely associated with risk of symptomatic gallstone disease after adjustment for potential confounders including age, smoking, physical activity, energy and coffee intake [hazard ratios (HRs) and 95% confidence intervals (CIs)] comparing the highest with the lowest quintiles: aMed: 0.66 (0.57-0.77), AHEI-2010: 0.64 (0.56-0.74) and DASH: 0.66 (0.58-0.76)]. Findings were similar after additional adjustment for body mass index and after inclusion of asymptomatic cases. Associations were stronger when analysis was restricted to cases who had undergone cholecystectomy. Conclusions: In this prospective cohort of male US health professionals, higher adherence to the aMed, AHEI-2010 and DASH diets was associated with lower risk of symptomatic gallstone disease. Dietary recommendations focusing on high-quality diets targeting symptomatic gallstone disease may lower the incidence of this prevalent disease.
DOI: 10.1093/ije/dyy210
Authors: Janine Wirth, Mingyang Song, Teresa T Fung, Amit D Joshi, Fred K Tabung, Andrew T Chan, Cornelia Weikert, Michael Leitzmann, Walter C Willett, Edward Giovannucci, Kana Wu
Institutions: Harvard University, Massachusetts General Hospital, Simmons University, The Ohio State University Wexner Medical Center, German Federal Institute for Risk Assessment (BfR), University of Regensburg
Language: English
Field: Medicine
Open Access status: bronze
Awards: Risk Prediction of Symptomatic Gallbladder Disease, G3034371047, Dietary Etiologies of Heart Disease, Marine Omega-3 Polyunsaturated Fatty Acid, Gut Microbiome, and Colorectal Cancer Prevention, Mentored Patient-Oriented Research in Digestive Diseases, Proinflammatory and hyperinsulinemic dietary patterns and colorectal cancer risk: role of the metabolome, Cancer Epidemiology Cohort in Male Health Professionals, G9000043482, G9000077387, G9000122174
OpenAlex ID: W2898050588
FWCI: 1.43
Cites: 55
Cited by: 32
Related to: 10