Work

PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex

Year: 2018

Type: article

Abstract: Heart rate and blood pressure control PIEZO1 and PIEZO2 are two mechanically activated ion channels that are highly expressed in lungs, bladder, and skin. Zeng et al. found that both ion channels are expressed in sensory neurons of a ganglion complex that contribute to the baroreflex, a homeostatic mechanism that helps to keep blood pressure stable (see the Perspective by Ehmke). Conditional double knockout of PIEZO1 and PIEZO2 in these neurons abolished the baroreflex and disrupted blood pressure regulation and heart rates in mice. These changes were very similar to those seen in patients with baroreflex failure. In mice, selective activation of PIEZO2-expressing ganglion neurons triggered immediate increases in heart rate and blood pressure. Science , this issue p. 464 ; see also p. 398

Source: Science

DOI: 10.1126/science.aau6324

Authors: Wei-Zheng Zeng, Kara L. Marshall, Soohong Min, Ihab Daou, Mark W. Chapleau, Francois M. Abboud, Stephen D. Liberles, Ardem Patapoutian

Institutions: Scripps Research Institute, Howard Hughes Medical Institute, Harvard University, University of Iowa, Iowa City VA Medical Center

Language: English

Topic: Heart Rate Variability and Autonomic Control

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Howard Hughes Medical Institute, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Neurological Disorders and Stroke, National Institute of Dental and Craniofacial Research, National Center for Complementary and Integrative Health

Awards: Sensory receptors of the vagus nerve, Integrative Neurobiology of Cardiovascular Regulation, Comprehensive Structural and Functional Mapping of the Mammalian Cardiac Nervous System, Role of mechanically activated ion channels in somatosensation, Mechanisms of force sensing in the nervous system

OpenAlex ID: W2898266525

FWCI: 27.03

Cites: 28

Cited by: 505

Related to: 10