Work

Spontaneous Mutational Frequency and FKS Mutation Rates Vary by Echinocandin Agent against Candida glabrata

Year: 2018

Type: article

Abstract: Echinocandins are front-line agents for treatment of invasive candidiasis. There are no reported agent-specific differences in Candida mutational frequency of resistance or propensity to develop FKS mutations.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01692-18

Authors: Ryan K. Shields, Ellen G. Kline, Kelley R. Healey, Milena Kordalewska, David S. Perlin, M. Hong Nguyen, Cornelius J. Clancy

Institutions: University of Pittsburgh, University of Pittsburgh Medical Center, Rutgers, The State University of New Jersey, Rutgers New Jersey Medical School, VA Pittsburgh Healthcare System

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Pfizer, Astellas Pharma, National Institutes of Health, National Institute of Allergy and Infectious Diseases

Awards: Caspofungin pharmacokinetics-pharmacodynamics during intra-adbominal candidiasis, Imaging and PK-PD of micafungin at sites of Candida glabrata infection in vivo, Critical Factors Influencing Echinocandin Resistance in Candida glabrata, G9000138776, G992149501

OpenAlex ID: W2898334442

FWCI: 4.342

Cites: 31

Cited by: 51

Related to: 10