A stochastic modeling framework for single cell migration: coupling contractility and focal adhesions
Year: 2018
Type: preprint
Abstract: The interaction of the actin cytoskeleton with cell-substrate adhesions is necessary for cell migration. While the trajectories of motile cells have a stochastic character, investigations of cell motility mechanisms rarely elaborate on the origins of the observed randomness. Here, guided by a few fundamental attributes of cell motility, we construct a minimal stochastic cell migration model from ground-up. The resulting model couples a deterministic actomyosin contractility mechanism with stochastic cell-substrate adhesion kinetics, and yields a well-defined piecewise deterministic process. Numerical simulations reproduce several experimentally observed results, including anomalous diffusion, tactic migration, and contact guidance. This work provides a basis for the development of cell-cell collision and population migration models.
Source: arXiv (Cornell University)
Author: Uatay, Aydar
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2898519933