Work

Prognostic Values of LAPTM4B-35 in Human Cancer: A Meta-analysis

Year: 2018

Type: review

Study designs: Systematic Review, Meta-Analysis

Abstract: Background: Lysosome-associated protein transmembrane-4β-35(LAPTM4B-35) has been observed overexpressed in multiple malignant tumors.However, the prognostic value of LAPTM4B-35 remains controversial.Therefore, we conducted a meta-analysis to evaluate the prognostic value of LAPTM4B-35 in human cancers.Methods: The relevant publications were obtained by systematically searching the PubMed, Web of Science, Embase, Wanfang, and China National Knowledge Infrastructure (CNKI) databases.Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated for the prognosis value of LAPTM4B-35 for cancer patient.Results: Our result suggest that LAPTM4B-35 overexpression is significantly associated with poor overall survival (OS) (HR = 2.49, 95% CI = 1.87-3.32,p < 0.001), disease-free survival (DFS) (HR = 2.43, 95% CI = 1.35-4.35,p = 0.003), and progression-free survival (PFS) (HR = 4.12, 95% CI = 2.30-7.37,p < 0.001).Moreover, subgroup analysis revealed significant association with poor OS in lung (HR = 2.05, 95% CI = 1.37-3.06,p < 0.001), gastric carcinoma (HR = 1.88, 95% CI = 1.01-3.50,p < 0.047) and ovarian cancer (HR = 4.94, 95% CI = 1.44-16.94,p = 0.011).Conclusion: LAPTM4B-35 may be a novel predictive biomarker and a potential target for treatment.

Source: Journal of Cancer

DOI: 10.7150/jca.26902