Year: 2018
Type: preprint
Abstract: Focal oncogene amplification and rearrangements drive tumor growth and evolution in multiple cancer types. We developed a tool, AmpliconArchitect (AA), which can robustly reconstruct the fine structure of focally amplified regions using whole genome sequencing. AA-reconstructed amplicons in pan-cancer data and in virus-driven cervical cancer samples revealed many novel insights about focal amplifications. Specifically, the findings lend support to extrachromosomally mediated mechanisms for copy number expansion, and oncoviral pathogenesis.
DOI: 10.1101/457333
Authors: Viraj Deshpande, Jens Luebeck, Mehrdad Bakhtiari, Nam-Phuong D Nguyen, Kristen M Turner, Richard Schwab, Hannah Carter, Paul S Mischel, Vineet Bafna
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2898975475