Magnetic resonance fingerprinting with quadratic RF phase for measurement of T2* simultaneously with δf, T1, and T2
Year: 2018
Type: article
Abstract: Purpose This study explores the possibility of using a gradient moment balanced sequence with a quadratically varied RF excitation phase in the magnetic resonance fingerprinting (MRF) framework to quantify T2* in addition to , T1, and T2 tissue properties. Methods The proposed quadratic RF phase‐based MRF method (qRF‐MRF) combined a varied RF excitation phase with the existing balanced SSFP (bSSFP)‐based MRF method to generate signals that were uniquely sensitive to , T1, T2, as well as the distribution width of intravoxel frequency dispersion, . A dictionary, generated through Bloch simulation, containing possible signal evolutions within the physiological range of , T1, T2, and , was used to perform parameter estimation. The estimated T2 and were subsequently used to estimate T2*. The proposed method was evaluated in phantom experiments and healthy volunteers (N = 5). Results The T1 and T2 values from the phantom by qRF‐MRF demonstrated good agreement with values obtained by traditional gold standard methods (r2 = 0.995 and 0.997, respectively; concordance correlation coefficient = 0.978 and 0.995, respectively). The T2* values from the phantom demonstrated good agreement with values obtained through the multi‐echo gradient‐echo method (r2 = 0.972, concordance correlation coefficient = 0.983). In vivo qRF‐MRF‐measured T1, T2, and T2* values were compared with measurements by existing methods and literature values. Conclusion The proposed qRF‐MRF method demonstrated the potential for simultaneous quantification of , T1, T2, and T2* tissue properties.
Source: Magnetic Resonance in Medicine
DOI: 10.1002/mrm.27543
Institution: Case Western Reserve University
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Case Western Reserve University, Siemens Healthineers, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Biomedical Imaging and Bioengineering, National Center for Advancing Translational Sciences
Awards: Assessing Mitochondrial Metabolism by Magnetization Transfer MR Fingerprinting, Comprehensive quantitative ultrafast 3D liver MRI, NRSA Training Core, Assessing Mitochondrial Metabolism using 31P Magnetic Resonance Fingerprinting, Phosphorus-31 MR Spectroscopic Imaging and Fingerprinting, Clinical and Translational Science Collaborative of Cleveland, G3447810086, Medical Scientist Training Program, Phenotypic characterization of nitric oxide regulation of cardiac function by MRI, Magnetic Resonance Fingerprinting (MRF) for Improved High Field MR, Improved Cardiac and Vascular MRI Using Parallel Imaging and Compressed Sensing, Optimization of MR Fingerprinting (MRF) for Quantitative MRI, Interdisciplinary Biomedical Imaging Training Program
OpenAlex ID: W2899141213