Work

The evaluation of complications and mortality in non-alcoholic steatohepatitis-related cirrhosis

Year: 2018

Type: article

Abstract: Objectives: Cirrhosis is seen in 4-8% of patients with nonalcoholicfatty liver disease (NAFLD), and death occurs in 1-5%of them due to hepatocellular carcinoma (HCC). The aim of thisstudy was to determine the factors associated with complicationsand mortality in patients with cirrhosis secondary to non-alcoholicsteatohepatitis (NASH).Materials and Methods: The patients with cirrhosis due toNASH diagnosed between 2008 and 2018 in our clinic formedthe study population. Patients with diabetes, obesity, or insulinresistance and those with cirrhosis due to other causes wereexcluded. The patients were enrolled and followed up prospectively.Results: A total of 185 patients were included in the study.The survival was 94.6% at the 1st year and 57.0% at the 5th year.Median survival duration was 5.83 years. The rate of HCCdevelopment was 0.7% at the 1st year and 9.7% at the 5th year. Inthe multivariate Cox analysis, age (OR: 1.12, 95% CI: 1.04-1.21;P = 0.003), creatinine (OR: 24.4, 95% CI: 2.32-257.8; P= 0.008)and encephalopathy (OR: 24.49, 95% CI: 1.06-19.6; p = 0.042)were found as independent predictors of mortality. Developmentof ascites occurred in 46.9%, variceal bleeding in 21.9% andencephalopathy in 18% of patients at the 5th year.Conclusion: Patients with NASH-related cirrhosis shouldbe carefully monitored for HCC development, variceal bleeding,ascites, and encephalopathy.

Source: Marmara medical journal

DOI: 10.5472/marumj.476330

Authors: Sezgin VATANSEVER, Zehra Betül PAKÖZ

Institutions: Izmir Kâtip Çelebi University, Sağlık Bilimleri Üniversitesi, Izmir Tepecik Eğitim ve Araştırma Hastanesi

Language: English

Topic: Liver Disease Diagnosis and Treatment

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2899155157