Differences in Daytime Sleepiness Between Parkinson's Disease Patients With and Without Sleep Apnea.
Year: 2013
Type: article
Study design: Observational Study
Abstract: INTRODUCTION : This project focused on the relationship between Parkinson's disease (PD) and Obstructive Sleep Apnea (OSA). Both of these conditions have high prevalence in the U.S., especially among the elderly population. Both of these conditions are also independently associated with excessive daytime sleepiness (EDS). The primary goal of this study was to examine whether there was a difference in daytime sleepiness between PD patients with (PD+OSA) and without OSA (PD-OSA). The hypothesis was that patients with PD and OSA would be sleepier during the day than patients with PD and no OSA. METHODS : The study included 86 patients (57 women, 29 men) with a mean age of 67.4 (SD 9.2) years. All participants enrolled in the study provided written informed consent. Participants completed an overnight screening polysomnogram (PSG) study followed the next day by a multiple sleep latency test (MSLT) and the following questionnaires: Epworth Sleepiness Scale (ESS), Parkinson's Disease Sleep Scale (PDSS), Pittsburg Sleep Quality Index (PSQI). A neurologist completed the Unified Parkinson's Disease Rating Scale (UPDRS) and the Clinical Global Impression Scale (CGIS). The criterion for being a part of the OSA group was an apnea-hypopnea index (AHI) of 10 or more. Of the 86 patients screened, 47 had an AHI>10. This project focused on the baseline data of the study. Statistical analyses compared PD+OSA vs. PD-OSA on subjective and objective measurements of daytime sleepiness. RESULTS : There were no statistically significant differences in subjective and objective measures of daytime sleepiness between the two groups of patients. Investigating the effects of PD medications by stratifying the patients on the basis of dopamine-agonist equivalent doses did not provide an explanation for the similarities in daytime sleepiness between the two groups. CONCLUSION : Although daytime sleepiness is common both in PD and in OSA, there were no significant differences in objective or subjective measures of daytime sleepiness in those wi.
Author: Emanuela Christati
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2899461900