Oxidative Stress and Age-related Diseases
Year: 2018
Type: conference-abstract
Abstract: Oxidative stress has long been implicated in the underlying mechanisms contributing to aging. Perhaps the most evident role of oxidative stress is in the initiation and progression of a number of age related diseases. Here we focus on a range of pathologies related to oxidative stress in animal and cell culture models. Work from the Van Remmen laboratory describes a promising new intervention for age related sarcopenia, a compound that activates the SERCA pump and helps to control calcium homeostasis. Data suggests that this compound can reduce muscle atrophy and weakness in the Sod1-/- mouse, a model of oxidative stress and sarcopenia. Dr. Rabinovitch will discuss a mitochondrial targeted treatment to reverse age-related functional declines. His team finds that that old mice that receive 8 weeks SS-31 (elamipretide) have improved muscle energetics and enhanced skeletal muscle and heart function, suggesting that short-term treatments can enhance mitochondrial function and reverse muscle aging phenotypes. Using primary cultures of retinal pigment epithelium (RPE) cells Dr. Ferrington has shown that RPE from AMD donors are more resistant to oxidative inactivation of two energy producing pathways (glycolysis and oxidative phosphorylation) and less susceptible to oxidation-induced cell death. Finally, data from Dr. Kasinath support a clear protective role for hydrogen sulfide generation in the aging kidney, reducing the aging-induced increase in urinary albumin excretion and inhibited matrix accumulation and reducing oxidative stress through via Nrf2 activation and decrease in NOX4 expression. These studies further support an important role for oxidative stress in age related pathologies.
Source: Innovation in Aging
Author: H Van Remmen
Institution: Oklahoma Medical Research Foundation
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,977
OpenAlex ID: W2899533131