Oxytocin and cholecystokinin correlates with Metabolic syndrome's atherogenecity and adiposity indices
Year: 2018
Type: article
Study design: Observational Study
Abstract:
OBJECTIVES our study aimed to investigate the correlation between plasma oxytocin (OXT) and cholecystokinin (CCK) as well as conicity index (CI), waist circumference (WC), waist circumference to hip circumference (WHR) ratio, red cell distribution width (RDW_CV%), mean platelet volume (MPV; fL) and TG\HDL-C ratio in metabolic syndrome (MetS) and Type-2 diabetes mellitus (T2DM) patients. METHODS In a cross-sectional design, 30 normoglycemic lean subjects (control), 30 nondiabetic MetS and 29 MetS-Pre/T2DM subjects were enrolled. Plasma OXT and CCK were measured by colorimetric-enzymatic assay and expressed as median (interquartile range). RESULTS CCK plasma levels (pmol\L) lacked pronounced discrepancy in MetS and MetS-pre/T2DM groups vs. lean –healthy controls (9.67 (7.14 – 13.7) and 6.73 (5.06 – 7.68) vs. 5.2 (2.86 – 7.56), respectively. OXT plasma concentrations (pg/mL) in both nondiabetic MetS and MetS-pre/T2DM groups were markedly (p 0.05) when compared to control group (10.35(9.08-11.03), vs. 9.3(8.55-9.9)). CONCLUSIONS In nondiabetic MetS and MetS-pre\T2DM patients; OXT circulating concentrations (unlike CCK) were substantially decreased vs. lean controls.
Author: taiba Al-Athami
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2899826065