Year: 2018
Type: article
Abstract: Nitroimidazoles are a class of structurally special heterocycles. The combination of five-membered aromatic heterocyclic imidazole and nitro group makes their derivatives to possess a wide variety of potential applications, and relevant researches of nitroimidazoles as drugs, artificial diagnostics, pathological probes and so on are quite active. In particular, nitroimidazoles as artificially synthetic chemical drugs have been widely used in the clinic for anticancers, antimicrobials, antiparasites etc.. Combining with our work and literatures in recent years, this work systematically reviewed the current researches and applications of nitroimidazole compounds in medicinal chemistry including antitumor, antibacterial, antifungal, antiparasitic, antitubercular, antihypertensive drugs as well as artificial diagnostics and pathological probes, supramolecular blocks. The foreseeable development trends were also prospected. This comprehensive review may provide a beneficial guide in the development of nitroimidazole heterocyclic compounds for multipurpose applications.
Source: Scientia Sinica Chimica
Institution: Southwest University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W2899893765