The Role of Mitochondrial Energetics in Cardiac and Skeletal Muscle Aging
Year: 2018
Type: conference-abstract
Abstract: Aging in both man and mouse is associated with significant declines in skeletal and cardiac muscle function, even in otherwise healthy individuals. We have studied whether short term pharmacologic treatments might be able to reverse these functional deficits. The mitochondrial protective SS-31 peptide (elamipretide) has recently been shown to bind to cardiolipin and improve respiratory chain function while reducing ROS. We have shown that brief treatment with elamipretide improves skeletal muscle ATP generation and fatigue resistance. Reduced proton leak is observed in both cardiomyocytes and skeletal muscles from aged mice after a single exposure. 24–26 month old mice that receive SS-31 for 8 weeks have improved skeletal muscle energetics, function and endurance, enhanced cardiac diastolic function, improved myocardial performance, reduced cardiac hypertrophy and increased exercise endurance. Thus, short-term treatments can enhance mitochondrial function and reverse muscle aging phenotypes in old mice. Support: NIH grants P01AG001751, P30 AG013280.
Source: Innovation in Aging
Authors: P Rabinovitch, D J Marcinek
Institution: University of Washington
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,977
OpenAlex ID: W2900083274