Microrna Regulated Transcriptomic Changes During Aging in Human Skeletal Muscle Reversible With Exercise Training
Year: 2018
Type: conference-abstract
Abstract: To gain insight into the potential mechanisms driving sarcopenia and the adaptive response to exercise, we conducted deep sequencing on vastus lateralis muscle obtained from healthy, younger and older subjects before and after a 4 month endurance training program. Muscle from women had 7 miRNAs and men had 8 miRNAs that changed with age and were reverted back to youthful levels with training, respectively. In older trained females these 7 miRNAs targeted 94 unique transcripts in the top 1000 differentially expressed genes between post-training compared to pre-training and these transcripts were involved in lipid metabolism, glycolysis, and growth. In older men the 8 miRNAs with youthful signatures after training had 146 unique targets involved in phosphoprotein and PI3K-AKT signaling. We conclude that some of the aging-related changes to the skeletal muscle transcriptome are under the regulation of miRNAs and that exercise training can reverse these changes.
Source: Innovation in Aging
Authors: J Valentine, J Gelfond, B Milholland, S Ghosh, N Musi
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,977
OpenAlex ID: W2900220335