Somatosensory Plasticity in Pediatric Cerebral Palsy following Constraint-Induced Movement Therapy
Year: 2018
Type: article
Abstract: is a widely used treatment for hemiplegic CP. However, effects of CIMT on somatosensory processing remain unclear. To examine potential CIMT-induced changes in cortical tactile processing, we designed a prospective study, during which 10 children with hemiplegic CP (5 to 8 years old) underwent an intensive one-week-long nonremovable hard-constraint CIMT. Before and directly after the treatment, we recorded their cortical event-related potential (ERP) responses to calibrated light touch (versus a control stimulus) at the more and less affected hand. To provide insights into the core neurophysiological deficits in light touch processing in CP as well as into the plasticity of this function following CIMT, we analyzed the ERPs within an electrical neuroimaging framework. After CIMT, brain areas governing the more affected hand responded to touch in configurations similar to those activated by the hemisphere controlling the less affected hand before CIMT. This was in contrast to the affected hand where configurations resembled those of the more affected hand before CIMT. Furthermore, dysfunctional patterns of brain activity, identified using hierarchical ERP cluster analyses, appeared reduced after CIMT in proportion with changes in sensory-motor measures (grip or pinch movements). These novel results suggest recovery of functional sensory activation as one possible mechanism underlying the effectiveness of intensive constraint-based therapy on motor functions in the more affected upper extremity in CP. However, maladaptive effects on the less affected constrained extremity may also have occurred. Our findings also highlight the use of electrical neuroimaging as feasible methodology to measure changes in tactile function after treatment even in young children, as it does not require active participation.
Source: Neural Plasticity
DOI: 10.1155/2018/1891978
Institutions: HES-SO University of Applied Sciences and Arts Western Switzerland, Vanderbilt University, Centre Hospitalier Universitaire Vaudois, HES-SO Valais-Wallis, Vanderbilt University Medical Center, University of Lausanne, The University of Queensland, Fondation Asile des Aveugles, Centre d'Imagerie BioMedicale, Nationwide Children's Hospital
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,830
Funders: National Science Foundation, Vanderbilt University, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Fondation Pierre Mercier, National Institutes of Health, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1182793083, Corpus der römischen Meilensteine, G2245779174, G2474448231, G3188738659, G327617862, G3280278470, G3403902456, G4382159607, G4425699080, G4666010418, G5576971692, G6116879466, G7051918440, The Vanderbilt Institute for Clinical and Translational Research (VICTR), Understanding the role of attention in visual rehabilitation: Amblyopia as a model, Core multisensory mechanisms: Closing in on real-world functions, The neural bases of building, discriminating, and remembering multisensory object representations in humans, G8632683379, The synaptic bases of mental diseases, APPLES: Early Childhood Constraint Therapy for Sensory/Motor Impairment in Cerebral Palsy, G880118091, G9000033427, G9000063385, G9000197111
OpenAlex ID: W2900224079