Work

Early detection of the aflatoxin B1 mutational fingerprint: A diagnostic tool for liver cancer

Year: 2017

Type: article

Abstract: Using duplex-consensus sequencing technology, we recently identified the characteristic high-resolution mutational spectrum of the liver carcinogen aflatoxin B1 in a mouse model, many months before aflatoxin-induced tumors are detectable. The diagnostic power of this spectrum is then demonstrated by accurately identifying, among the sequenced human liver tumors, the subset of cancers associated with aflatoxin B1 exposure.

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2017.1329693

Authors: Bogdan I. Fedeles, Supawadee Chawanthayatham, Robert G. Croy, Gerald N. Wogan, John M. Essigmann

Institution: Massachusetts Institute of Technology

Language: English

Topic: Cancer Genomics and Diagnostics

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,590